It was initially available with a 60MHz PowerPC 601 processor in standard and "AV" configurations. A 66MHz version was introduced in January 1995. Performa and Work Group Server variants were also released. A PC option included a 66MHz Intel 486DX2 processor on a NuBus card that allowed support for DOS and Windows.
The 6100 retains the case design of the Quadra 610 and is the flattest among the first three Power Macs. The casing was neatly divided into three thirds. The first third contained the Apple logo and the painted name Power Macintosh 6100 (with minor variations based on the speed of the Power Mac). The second third contained the CD-ROM drive. The floppy drive was on the top part of the final third, with the pea-sized, embossed power button on the lower right-hand corner of the final third.